Investor Presentation Full Year 2021

36 Investor presentation Full year 2021 Novo NordiskⓇ People with diabetes have increased mortality risk with eight years shorter life expectancy, highlighting the importance of innovation Diabetes is associated with shorter life expectancy and lower quality of life The unmet need remains large within diabetes Untreated (million) Treated with competitors' products (million) Treated with Novo Nordisk' products (million) 463 • Life expectancy 8 years shorter¹ Diabetes • Driven by 200% increased risk of all cause mortality¹ CVD • 70% of people with diabetes die from atherosclerotic CVD² • 150% increase in risk of stroke³ • Higher likelihood of neuropathy, Organs retinopathy, limb amputation, cancer and cognitive dysfunction4 183 35 Diabetic population5 Other OAD Insulin Branded OAD GLP-1 1 Diabetes Care 2017 Mar; 40 (3): 338-345; 2 https://www.who.int/cardiovascular diseases/en/; ³ https://www.diabetes.org/diabetes/complications/stroke.; CVD: Cardiovascular disease; OAD: Oral anti-diabetic; 4 Diabetes Care 2005 Jan;28(1):164-176 5 IDF Diabetes World Atlas, 2019, 9th edition

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