Benevolent Platform Precision Medicine

Target prediction ° 00 00 00 1. Data Preparation 2. Target Prediction 3. Target Triage 4. Target Validation Focus and curate a biological question Graph Completion Human Queries 1 2 3 4 Target Safety Drugs? Metadata Score MIM Tgt1 Safe Tgt2 Unsafe No Partial OPC, GCNN 0.71 SQT 0.65 Reinforcement Learning 'omics Tgt3 Tgt4 Safe Yes OPC, CROM 0.51 PhaseII Offtgts OPC 0.49 Model fleet predictions Prediction evaluation Equip experts with data Triage predictions Perform Assays Analysis & retro 1. Disease Data Package 2. Predictions Package 3. Hypothesis Package 4. Validated Hypothesis Package Benevolent 18

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