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Investor Presentaiton

Balanced Revenue Contribution and Robust Growth Profile 19% RMS Total Revenue 61% DSA 20% Manufacturing* Research Models Research Model Services Human Cellular Products (Cell Supply) 9.0% Organic growth FY 2022 25.2% Non-GAAP operating margin FY 2022 - Discovery Services - Safety Assessment 17.5% Organic growth FY 2022 25.3% Non-GAAP operating margin FY 2022 Microbial Solutions Biologics Testing C&GT CDMO 5.3% Organic growth FY 2022 28.8% Non-GAAP operating income FY 2022 Charles River Laboratories (CRL) See ir.criver.com for reconciliations of GAAP to non-GAAP results. All revenue and operating income/margin figures based on FY 2022 financial information. *Note: Charles River completed the previously announced divestiture of the Avian Vaccine business in December 2022. Avian is included in the FY 2022 figures above. 7
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