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Reimagining Medicine

Company overview Innovation: Pipeline overview Cardiovascular Ophthalmology Financial review Immunology aflibercept - VEGF inhibitor NCT04864834 Mylight (CSOK583A12301) Ophthalmology indication (as originator) Phase 3 Indication Phase Patients 460 2023 priorities Innovation: Clinical trials Neuroscience Global Health Primary Outcome Measures Arms Intervention Best-corrected visual acuity (BCVA) will be assessed using the ETDRS testing charts at an initial distance of 4 meters. The change from baseline in BCVA in letters is defined as difference between BCVA score between week 8 and baseline Arm 1 Biological: SOK583A1 (40 mg/mL) Arm 2 Biological: Eylea EU (40 mg/mL) Patients with neovascular age-related macular degeneration Target Patients Readout 2023 Milestone(s) Publication tbd Appendix Abbreviations Oncology Other Biosimilars 105 Investor Relations | Q4 2022 Results NOVARTIS | Reimagining Medicine
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