Investor Presentaiton

Investor Presentation First nine months of 2018 Slide 64 Solid insulin market leadership position in Region Japan & Korea Region Japan & Korea insulin market by segment Region Japan & Korea modern and new- generation insulin volume market shares Sanofi Novo Nordisk - Eli Lilly tMU 18 16 14 12 10 8- 6 2 0 Aug 2013 Device penetration CAGR volume¹: 0.6% MI and NGI penetration Penetration CAGR value¹: (3.1%) 100% 70% 60% 80% Fast-acting 50% 60% 40% Premix 30% 40% 20% Long-acting 20% 10% 0% 0% Aug 2018 1 CAGR for 5-year period MI: Modern insulin; NGI: New-generation insulin Source: IQVIA monthly MAT Aug, 2018 volume and value (DKK) figures changing diabetes® Aug 2013 Source: IQVIA monthly MAT Aug, 2018 volume figures 50% 26% 24% Aug 2018 novo nordisk

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