Semaglutide Weight Management and Cardiovascular Risk Reduction
Obesity is associated with multiple comorbidities, which may be
improved with weight management
Life expectancy decreases as BMI increases¹
Obesity related comorbidities²
Normal BMI
Almost 80% chance of reaching age 70
Mental
⚫ Depression
Anxiety
BMI 35-40 kg/m²
~60% chance of reaching age 70
BMI 40-50 kg/m²
-50% chance of reaching age 70
Mechanical
Asthma
GERD
Physical functioning
• Incontinence
Knee osteoarthritis
Sleep apnea
Chronic back pain
Metabolic
NAFLD
Gallstones
Infertility
Type 2 diabetes
Prediabetes
Thrombosis
Gout
Cancers*
CVD:
•
Stroke
Dyslipidemia
•
Hypertension
Coronary artery
disease
HFPEF
*Including breast, colorectal, endometrial, oesophageal, kidney, ovarian, pancreatic and prostate
1 Prospective Studies Collaboration. Lancet. 2009;373:1083-96. 2 Adapted from Sharma AM. Obes Rev 2010;11:808-9; Guh DP et al. BMC Public Health 2009;9:88; Luppino FS et al. Arch Gen Psychiatry 2010;67:220-9; Simon GE et al. Arch Gen Psychiatry
2006;63:824-30; Church TS et al. Gastroenterology 2006;130:2023-30; Li C et al. Prev Med 2010;51:18-23; Hosler AS. Prev Chronic Dis 2009;6:A48.
BMI: Body mass index; GERD: gastro-oesophageal reflux disease; HFPEF: heart failure with preserved ejection fraction; NAFLD: non-alcoholic fatty liver disease; CVD: Cardiovascular disease; HFPEF: Heart failure with preserved ejection fractionView entire presentation