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Novartis Investor Presentation

New Novartis: Our strategy Our focus Core Therapeutic Areas > Technology platforms Priority geographies Capital allocation / structure Our priorities Conclusion Abbreviations Building the industry-leading RLT platform Established leadership in RLT, category creator and positioned as the go-to partner for collaborations Robust manufacturing delivering safety and quality ■ 4 manufacturing facilities: Ivrea (Italy), Milburn (US), Zaragoza (Spain) & Indianapolis (US, opening 2023) At scale manufacturing & "just-in-time" production/delivery On track for additional non-carrier added isotope production Strong commercial execution with >500 centers and >16,000 patients treated Leading with the science ▪ 4 ongoing registrational studies (next readout PSMAfore Q4'22) ■ 8 dedicated early discovery projects Selected compound (indication) Lutathera (1L GEP-NET) Lutathera (Pediatrics + PPGL)1 Lutathera (GBM)² Lutathera (ES-SCLC)² Pluvicto (mHSPC) Pluvicto (mCRPC) 225AC-PSMA-617 (PCa+bone metastases) NeoB (multi tumor) 1. PPGL, is an exploratory cohort of NETTER-P 2. Phase 1/2 12 Novartis Investor Presentation | September 22, 2022 2. Technology platforms - RLT Phase 1 Phase 2 Phase 3 U | NOVARTIS | Reimagining Medicine
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