First Quarter 2018 Investor Presentation

Investor Presentation First three months of 2018 Slide 108 Stable ownership structure - secured through A and B-share structure Share structure Novo Nordisk Foundation Novo Holdings A/S 76.2% of votes 28.5% of capital Institutional and private investors 23.8% of votes 71.5% of capital The Novo Nordisk Foundation The Novo Nordisk Foundation is a self-governing institution that: • provides a stable basis for Novo Nordisk • supports scientific, humanitarian and social purposes • All strategic and operational matters are governed by the board and management of Novo Nordisk . Overlapping board memberships ensure that the Novo Nordisk Foundation and Novo Nordisk share vision and strategy A shares 537m shares B shares 1,913m shares Novo Nordisk A/S Note: As of 24 April 2018. Treasury shares are included in the capital but have no voting rights changing diabetes novo nordisk

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