Q1 2022 Results slide image

Q1 2022 Results

Company overview Financial review 2022 priorities Appendix References Strong KesimptaⓇ launch in a suppressed market* US MS market* growth still suppressed NBRX 34k 30k 28k 27k. 23k' Q1/21 Q2/21 Q3/21 Q4/21 Q1/22 Sales evolution 1 GROWTH CE Z K Kesimpta L Accelerating launch momentum " About 20k patients treated, >60% naive or first switch4 US: strong growth despite suppressed market dynamics Ex-US: approved in 68 countries Strengthening differentiation and benefit/ risk profile " Up to 4 years data show continued reduced risk of disability worsening and stable IgG levels (ASCLEPIOS/ALITHIOS)1,2 Majority of Kesimpta treated patients can mount a robust immune response after COVID-19 vaccination; may be distinct amongst B cell treatments³ USD m Ex-US US 195 ■ 147 109 66 50 Q1/21 Q2/21 Q3/21 Q4/21 Q1/22 *Refers to dynamic market. NBRX - New to brand Prescription IgG - Immunoglobulin G mRNA-messenger Ribonucleic Acid. See References at end of this presentation. 12 Investor Relations | Q1 2022 Results ✓ NOVARTIS | Reimagining Medicine
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