Investor Presentaiton
GOD Potency
sanofi
All four LNP components leave significant room for optimization
84 Vaccines Investor Event
Ionizable lipid
Helper lipid
Cholesterol
The ionizable lipid wraps around the mRNA and helps
transport and release it to the targeted cell
The helper lipid helps create the lipid membrane of
the LNP, and it allows for the LNP to easily fuse to the
mRNA's target cell and endosomal membrane
Cholesterol enhances the stability of the LNP and ensures
it is sturdy and rigid. This assists with the introduction of
the mRNA into the cells
PEGylated lipid
Polyethylene glycol, or a PEG lipid, is what helps maintain
the overall physical nanostructure of the LNP and protects
the mRNA nanoparticles from the body's natural clearance
mechanismsView entire presentation