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Investor Presentaiton

NAO In the full year 2022, Rybelsus® sales account for 24% share of growth of NAO sales Total Rybelsus® TRx volume is steadily growing in the US 137 Investor presentation Full year 2022 RybelsusⓇ and SGLT-2i¹ uptake in the US² since respective launches TRX count (000s) 100 80 60 60 60 40 40 20 20 Rybelsus® TRX SGLT-2i TRX 82 0 0 31 62 тури 65 • 93 124 155 Time since launch (weeks) • Successful RybelsusⓇ launch despite COVID-19 impacting the first year of launch RybelsusⓇ TRX continues to steadily increase . Achieved global blockbuster status in 2022 1SGLT-2i is an average of empagliflozin and canagliflozin script count. 2RybelsusⓇ is based on Oct 2019 focus launch. Each data points represents a rolling four-week average. Note: TRx: Total prescription data; NAO: North America Operations; Source: IQVIA Xponent, Week ending 6th Jan 2023
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