American Thoracic Society - Sanofi Investor Call

COPD with Type 2 Inflammation is Associated with More Frequent COPD Exacerbations: The COPDGene Study Eosinophil <n ≥n IRR 95% CI cut-off 100 cells/μL 223 1330 1.16 0.90-1.52 200 cells/uL 814 739 1.24 1.04-1.48 300 cells/uL 1187 366 1.32 1.08–1.61 340 cells/μL 1350 203 1.50 1.18-1.91 400 cells/μL 1398 155 1.60 1.24-2.08 2% 408 1145 1.22 0.99-1.50 3% 859 694 1.18 0.99-1.40 4% 1166 387 1.35 1.11-1.63 5% 1334 219 1.63 1.30-2.05 A blood eosinophil cut-off of 300 cells/µL identified a subgroup of ~20% of the study population who were at risk of frequent exacerbations ATS 2023 1.00 2.00 Incidence Rate Ratio 4.00 Yun JH, et al. J Allergy Clin Immunol. 2018;141:2037-2047 18

View entire presentation