Investor Presentaiton

Years lived with disability (millions) 20 100 120 ONENESS Back pain Depression DFU - Top 10 Costly Disease DFU has caused huge medical burden worldwide Common, Complex, Costly WHO Global Burden of Disease Diabetes Diabetes-related lower extremity complications CKD IHD CVD 1 2 3 4 5 6 7 8 9 10 11 24 25 27 >30 mn DM patients with a foot ulcer worldwide1 19-34% life-time incidence on DM patients² 30-40% recurrence on DM patients within 1 yr³ 1/3 medical costs spent on lower limbs4 1 Zhang P, et al. Ann Med. 2017 Mar;49(2):106-116. 12 N Engl J Med 2017;376:2367-75 | 3 Zhang Y, et al. Diabetes Care 2020 May; 43(5): 964-974. | 4 J Foot Ankle Res. 2020 Mar 24;13(1):16. | 9

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