EVOLUTION AT MERCK - INVENTING FOR LIFE

INNOVATIVE PORTFOLIO AND WAVE OF INDICATIONS DRIVING GLOBAL GROWTH +4% Growth Contributors: GARDASIL KEYTRUDA JANUVIA +67% +9% Europe¹ Hospital Acute Care China Japan -4% +12% United Canada Growth Contributors: KEYTRUDA GARDASIL Pediatric Vaccines BRIDION Lynparza Lenvima States Growth Contributors: KEYTRUDA Pediatric Vaccines +25% GARDASIL Hospital Acute Care Latin America Growth Contributors: +14% KEYTRUDA GARDASIL Pediatric Vaccines BRIDION Eastern Europe / Middle East Africa Growth Contributors: GARDASIL Pediatric Vaccines BRIDION +3% Asia Pacific Ex-China Growth Contributors: KEYTRUDA Lenvima Lynparza BELSOMRA Human health sales outside of the U.S. grew 12% in 1Q 2019 All growth rates exclude the impact of exchange and represent 1Q 2019 vs. 1Q 2018. Growth contributors represent select growth drivers across pillars of growth. 1 Europe primarily represents all European Union countries and the European Union accession markets MERCK INVENTING FOR LIFE Frank Clyburn 27 27

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