Comera Investor Presentation Deck

Effect of stabilizers on Freeze thaw stability of mAbs 1000000 100000 10000 1000 100 10 1 Ctrl Nivolimumab FT with stabilizers CS3 Treh 100000 10000 1000 100 10 1 Suc Ctrl particles/ml ■2-10 nm 10-20 nm ■20-50 nm CS3 1000000 CS1 100000 10000 1000 100 10 1 Pembrolizimumab FT with stabilizers CTRL Treh Suc Treh HGG FT with stabilizers CS1 Stabilizer particles/mil ■2-10 nm 10-20 nm CS4 ■ 20-50mm CS3 Sucr total 2-10um >10um >25um ● Comera LIFE SCIENCES mAb conc: 10 mg/ml saccharide conc: 0.2M 10 FT cycles Samples analyzed by flowcam Stabilizers showed effectiveness in preventing particulate formation due to freeze thaw stress 13

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