Comera Investor Presentation Deck

MD simulation data of protein excipient interaction 10 ns time scale Excipient Protein Ligand RMSD (nm) 0.8 06 04 02 RMSD (nm) RMSD Hackbone after hq fit to Backbone 4 Time (m) RMSD LIG after sq fit to Protein уни ду мучилист 4 6 Time (ts) 10 10 Number 340 300- 310 300 280 05- 10 9 20000 2000 Hydrogen Bonds 4x8 4000 Time (4) Time (ps) 10X00 10000 8000 Simulation data allows to identify regions 1. 2. 3. 4. 5. Comera LIFE SCIENCES Where the excipient binds How the excipient binds Strength of binding Interaction time Residues it can interact with MD Simulation gives a better predictive power and more reliable analysis of protein-ligand dynamics and improve screening results 9

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