23andMe Investor Presentation Deck
Leveraging Pleiotropy to Expand Airway Target Space
Hypothesis: loci associated with related phenotypes prioritize biologies not addressed by standard of care
epithelial biology:
screen mucociliary function
in ALI culture
genetic determinants of
obstructive airway disease
sensory neuron biology:
screen in iPSC-derived
neuron models
genetic determinants of
airway hyper-reactivity
COPD
> 200 loci
+
neuro-
inflamm
>500 loci
asthma
>600 loci
eczema
>500 loci
+
urticaria
> 300 loci
genetic determinants of
allergy/T2 inflammation
genetic determinants of
mast cell pathology
Pleiotropy + functional genomics = best targets
T2 cytokine biology:
deprioritize or develop
SM/inhaled modality
mast cell biology:
screen in IgE dependent &
independent assays
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