Bionomics Investor Presentation Deck

BNC210 Anti-Anxiety Signals Observed in Animal Models and Human Translational Studies People with anxiety disorders and PTSD have amplified fear responses to trauma- or stress-related stimuli and impaired fear extinction Bionomics Time Spent Freezing (sec) Conditioned Fear Extinction Model 175 150- 125 100 75 50 25 0 1 T 2 * 3 4 Days after Conditioning Diazepam (0.5 mg/kg) Vehicle BNC210 (100 mg/kg) P = 0.03 p = 0.01 *Time in minutes after CCK-4 injection CCK-4 = Cholecystokinin Tetrapeptide (a peptide that induces anxiety and panic symptoms) eVAS Emotional Visual Analog Scale 5 6 BNC210 enhanced fear extinction following conditioned response training eVAS Score Emotional Visual Analog Scale (eVAS) 10 -10 -20 -30 Recovery to Baseline BNC 210 5 10 15 20 60 Placebo Recovery to Baseline 5 10 15 20 60 Minutes (Post-Panic Attack)* BNC210 enhanced emotional recovery following a CCK-induced panic attack 16

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