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Investor Presentaiton

Investor Presentation First six months of 2018 Slide 47 Novo Nordisk's modern and new generation insulins have a stable market position in the USA insulin market USA fast-acting insulin Segment volume USA premix insulin Segment volume USA long-acting insulin Segment volume Levemir® share NovoLogⓇ share NovoLog® Mix 70/30 share TresibaⓇ share tMU tMU tMU CAGR volume¹: 3.1% 80 MI penetration: 83.9% 100% 80 CAGR volume¹: (6.2%) MI penetration: 52.0% CAGR volume¹: 3.8% 100% 80 MI penetration: 73.7% 100% 70 70 70 80% 80% 80% 60 60 60 50 - 60% 50 60% 50 60% 40 40 40 40% 30 30 40% 30 40% 20 20 20 20% 20% 20% 10 10 10 0 0% 0% 0 0% 0 May 2013 May 2018 May 2013 May May May 2018 2013 2018 1 CAGR for 5-year period; tMU: Thousand mega units Note: US trend data reflect changes to IQVIA data collection coverage and methodology as of January 2012. Modern insulin (MI) penetration is of total segment, ie including human insulin Source: IQVIA monthly MAT May, 2018 volume figures changing diabetes® novo nordisk
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