Investor Presentation

125 Investor presentation First six months of 2022 Insulin market size and volume market share in Rest of World Total Insulin market share and market size (DKK billion) 58% Long- Acting 41% 5 Fast- Acting 62% 2 Premix 83% 2 Human 66% 2 Rest of World Market growth A Market share Insulin volume: market share 80% 20% 11 5.6% +1.7% 60% 15% 57% 9.0% +2.5% 10% 40% 5% 2.9% +1.1% 20% -2% 0% 4.1% +2.6% -2% 0% -5% May May 2019 -NN market share 2022 3.1% +1.6% Market growth (right axis) ―NN growth (right axis) Novo Nordisk Competitors Source: IQVIA, May 2022; LHS graph - Value, RHS Graph - Volume, MAT; Share of growth not depicted due to too high numbers; NN: Novo Nordisk

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