Investor Presentaiton

Ligand directed degraders (LDD) complement CELMODs in our approach to Targeted Protein Degradation Different from Same as CELMODS Ill Bristol Myers Squibb™ CELMODS E2 E3 ligase Ub NH₂ Target Protein Heterobifunctional molecule E2 E3 ligase LDD molecule recycling Ubiquitination NH₂ Ternary complex Ub NH2 Peptide fragments Proteasome Polyubiquitination Proteasomal degradation Early Development AR LDD: Prostate BCL6 LDD: Lymphoma IND-enabling studies LDD: Prostate LDD: Autoimmune Not for Product Promotional Use 38

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