Investor Presentation - First Six Months of 2021

55 Investor presentation First six months of 2021 Novo Nordisk® Global obesity market share, market growth, and US volume and value market Obesity market growth and Novo Nordisk 80% 60% 40% 20% 0% May 2018 value market share Obesity market size and growth US obesity care market remains small at around USD 853 million DKK TRX SU billion market share mUSD/value market share 60% ~ -1% 100 900 67% 50% 10.0 [0.5 10.0 0.6 88 40% 30% 60 80 600 60 -9% 20% 40 10% 61% -1% 40 300 67% 20 0% -10% 0 0 May May SaxendaⓇ Others 2021 2020 May 2021 Volume Value Generic Other branded AOM Saxenda Ⓡ NN market share Market growth (right axis) Source: IQVIA, May 2021 Value MAT, all countries; IQVIA Xponent Volume MAT, May 2020 and NSP MAT, May 2020.

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