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Investor Presentaiton

Cardiovascular milvexian Camzyos MYK-224 Opportunity for sustained leadership in Cardiovascular 1 Successful history of developing leading CV medicines (e.g., Plavix & Eliquis) Extending our leadership in thrombotic diseases • Milvexian: Robust Phase 2 program supported differentiated clinical profile; Phase 3 studies in SSP, ACS and AF underway Potential opportunity for myosin inhibitors in cardiomyopathies and heart failure Camzyos: Expansion into nHCM with Ph3 trial underway MYK-224: Initiating PoC trial in HFPEF based on supportive data Addressing cardiovascular diseases impacting 17M+1 patients Ill Bristol Myers Squibb 1. Source: 2023 estimates from Decision Resource Group & BMS Internal Analysis across indications in the U.S. & EU5 Not for Product Promotional Use 125
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