Investor Presentaiton

INspire: Intracellular delivery of anti mutated K-RAS protein (in-vitro PoC) Anti-K-RASG12V protein internalized into lung adenocarcinoma cells and localizes to K-RAS sites (inner-side of cell membrane) Effect of intracellularly delivered anti-K-RAS protein agent on apoptosis of KRASG12D pancreatic ductal carcinoma cell line Apoptosis (Annexin V staining) 30000 25000 20000 15000 10000 5000 Chemical Modifications Antibody Payload HA 20 40 60 80 100 Time (hr) Annexin V staining - A common method for detecting apoptotic ("dying") cells BIOND BIOLOGICS Carrier Biond Biologics Corporate Presentation | May 2021 | Non-confidential 36

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