Investor Presentaiton

Breast Bone Brain A favorable safety profile Cardiovascular system Liver Uterus & vagina . Similar to other estrogens, Estetrol has also a beneficial and positive impact on the cardiovascular system, brain, bone and endometrium Unlike other estrogens, Estetrol has a limited impact on the liver and breast Breast: mixed activity on breast cell proliferation, migration and invasion1, limited impact on breast at therapeutic dose Liver: • minimal impact on Sex Hormone Binding Globulin (SHBG) synthesis • minimal impact on synthesis of coagulation factors (lower risk of VTE) limited lipid impact (including Triglycerides) Cardiovascular system 1. In presence of Estradiol (E2) Visser et al. Climacteric 2008 | Mawet et al. Eur J Contracept Reprod Health Care 2015 | Gérard et al. J Endocrinol 2015 | Abot et al. EMBO Mol Med 2014| Coelingh Bennink et al. Climacteric 2008 | Heegaard et al. Climacteric 2008 | Holinka et al. Biol Reprod. 1980 | Holinka et al. Climacteric 2008 | Pluchino et al. J Steroid Biochem Mol Biol 2014 | Tskitishvili et al. Exp Neurol 2014 Guivarc'h et al. J Am Heart Assoc 2018 | Kluft et al. Contraception 2017 | Douxfils et al. Contraception 2020 | Klipping et al. Contraception 2021 Mithra Investor Presentation - November 2023 14

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