Dare Bioscience Investor Presentation Deck
Statistically significant increases in Vaginal Pulse
Amplitude (VPA)¹
Pfizer VPA Clinical Lab Study - Oral Viagra
Vaginal Pulse Amplitude (mv)
Oral Sildenafil provided a compelling proof of concept for FSAD
Mean and Maximum VPA+
5
P=0.093
Mean (Erotic)
Placebo
+ Twelve healthy premenopausal
women were studied.
Oral Viagra
P<0.05
Maximum (Erotic)
Statistically significant improvement in genital
stimulation (FIEI)²
Pfizer Clinical Field Study - Oral Viagra
Observed Number Improved (%)
Improvement on FIEI Questionst
70
60
50
40
30
20
10
0
P=0.017
Question 2
Placebo
Oral Viagra®
P=0.015
Question 4
+ Question #2 - "After taking study medication, the
sensation/feeling in my genital (vaginal, labia, clitoris) area
during intercourse or stimulation (foreplay) seemed to be: (a)
more than before, (b) less than before, or (c) unchanged".
1. The Enhancement of Vaginal Vasocongestion by Sildenafil in Healthy Premenopausal Women. Journal of Women's Health & Gender-Based Medicine. Vol. 11, No. 4. 2002
2.Safety and Efficacy of Sildenafil Citrate for the Treatment of FSAD: A Double-Blind, Placebo Controlled Study. The Journal of Urology. Vol 170, 2333-2338, December 2003.
Question #4 - "After taking the study medication, intercourse
and/or foreplay was: (a) pleasant and satisfying; better than
before taking the study medication, (b) unpleasant; worse than
before taking study medication, (c) unchanged; no difference,
or (d) pleasant; but still not like it used to be or I would like it to
be."
202 postmenopausal women with FSAD who had protocol
specified estradiol and free testosterone concentrations, and/or
were receiving estrogen and/or androgen replacement therapy
were studied.
Key Takeaways of Viagra® studies:
•Increased blood flow and clinical efficacy observed with oral sildenafil (Viagra®) in women.
•The side effect profile of the oral formulation was not optimal for women - leading to the exploration of alternative delivery options including a topical route of
administration.
35
IView entire presentation