BenevolentAl Therapeutics Pipeline and Triage

Prediction strategy geared for identification of fibrotic regulators driven through oxidative stress Target identification and hypothesis validation strategies were aligned to identify targets that could impact: • Fibrosis (hepatic stellate cell activation assay) ⚫ Steatosis (hepatocyte lipid accumulation assay) Models were trained using datasets focussed on: • NAFLD disease biology • Oxidative stress mechanism 1 Define biological question and assays 2 Transcriptomics data selection 3 Models run Normal liver First hit Insulin resistance ↓ẞ-oxidation ↑ De novo fatty acid synthesis 4 Target Triage NAFLD NASH Fibrosis/Cirrhosis 5 Second hit Hypothesis validation ↑ Oxidative stress Necroinflammation and inflammation Targets A & B ΑΙ Benevolent 60

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