Investor Presentation First Nine Months of 2022

139 Investor presentation First nine months of 2022 Insulin market size and volume market share in North America Operations Total Insulin market share and market size (DKK billion) Long- acting 37% 42% Fast- 51% 78 acting 59% Premix 8 108 26% Human 15 Novo Nordisk Competitors NAO Market growth A Market share Insulin volume: Market share 60% 12% 209 5.9% +0.1% 5.5% +0.1% 40% 8% 38% 4% -1% 0% 8.3% +0.2% 20% -5.4% +0.9% 0% Aug 2019 4.2% -1.7% Note: Insulin market numbers do not reflect rebates. Source: IQVIA, Aug 2022, LHS graph - Value, RHS Graph - Volume, MAT, all countries. Share of growth not depicted due to too high numbers; NN: Novo Nordisk -4% -4% -8% Aug 2022 NN market share -Market growth (right axis) -NN growth (right axis).

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