Investor Presentation Full Year 2017

Investor Presentation Full year 2017 Slide 42 The insulin market is comprised of three segments 6:00 Insulin action profiles tMU 500 Global insulin volume market by segment CAGR volume¹: 4.4% CAGR value¹: 16.8% Fast-acting 400 35% Fast-acting 34% 300 Premix 26% 200 Premix 29% Long-acting 100 40% 37% Long-acting 0 10:00 14:00 18:00 22:00 2:00 6:00 ↑ ↑ ↑ Time of day Nov 2012 Nov 2017 Breakfast Lunch Dinner 1 CAGR for 5-year period. Value in DKK changing diabetes® Source: IQVIA (formerly IMS) monthly MAT volume and value Nov 2017(DKK) figures novo nordisk

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