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Investor Presentaiton

111 Investor presentation Full year 2022 International Operations at a glance. Diabetes trend Million Diabetes market by value and Novo Nordisk market share Novo Nordisk reported sales 600 400 200 0 M 487 2021 587 2030 Population with diabetes Diabetes growth rate DKK billion 19% 250 17% Full year 2022 Sales (mDKK) Growth² 80% Total GLP-13 26,196 57% Long-acting insulin4 11,403 -1% 200 36.7%1 60% Premix insulin5 10,023 -9% GLP-1 Fast-acting insulin 10,826 -3% 150 Human insulin Insulin 6,508 -18% 720 3.9%1 40% Total insulin 38,760 -7% 100 Other Diabetes care? 2,428 -11% 20% Diabetes care 67,384 10% 50 8.5%1 OAD Obesity care8 5,886 82% 0 0% Diabetes & Obesity 73,270 14% Nov 2045 2017 Nov 2022 care Rare disease⁹ 12,577 5% GLP-1 MS -Insulin MS -OAD MS Total 85,847 13% Novo NordiskⓇ Diabetes trend estimates based on the following International Diabetes Foundation defined regions: Africa, Europe, Middle East and North Africa, South and Central America, South East Asia and Western Pacific; Source: International Diabetes Federation: Diabetes Atlas 10th Edition 2021 1 CAGR calculated for 5-year period; Competitor insulin value market shares, as of Nov 2022: Novo Nordisk 51%, Sanofi 27% and Eli Lilly 13%; Competitor GLP-1 value market shares, as of Nov 2022: Novo Nordisk 64%, Eli Lilly 34% and AstraZeneca 1%; OAD: Oral anti-diabetic; MS: Market share; Source: IQVIA MAT, Nov 2022 value figures 2 At Constant exchange rates; 3 Comprises Victoza®, Ozempic®, and RybelsusⓇ; 4 Comprises TresibaⓇ, XultophyⓇ and Levemir®: 5 Comprises RyzodegⓇ and NovoMix®; 6 Comprises FiaspⓇ and NovoRapidⓇ: 7 Comprises Novo NormⓇ and needles; 8 Obesity care comprises SaxendaⓇ and Wegovy®: 9 Comprises primarily NovoSeven®, Novo Eight®, NovoThirteen®, Refixia®, EsperoctⓇ, Norditropin®, Vagifem® and ActivelleⓇ
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