Investor Presentaiton

ONENESS DFU Treatment Market Opportunity DFU Unmet Medical Need Creates > US$ 14 Billion Market Opportunity for an Effective DFU New Drug ~US$14.8B 2030E ~US$5.1B 2024E The real market demand is anticipated to be multiplied by the launch of an effective new drug US$2.1B 2019 19.2% 2019-24E CAGR >30M DFU patients globally >1.2M amputations/year Source: Frost & Sullivan analysis, International Diabetes Federation, Diabetes Care 2014 Mar; 37(3): 651-658 | Eleftheriadou I, Tsapogas P, Tentolouris A, et al. | 10

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