RSV Seasonal Vaccine Introduction and Growth Strategy slide image

RSV Seasonal Vaccine Introduction and Growth Strategy

HIV +12% growth in Q2 2023 driven by oral 2DR and long-acting regimens Strong commercial execution across HIV portfolio Sales £m 40% 30% 1000 60% 900 51% 46% 47% 50% 800 42% 700 39% 36% 600 33% 28% 500 26% 25% 400 300 200 100 0 Q1 Q2 Q3 2021 2021 2021 Q4 Q1 Q2 Q3 Q4 Q1 Q2 2021 2022 2022 2022 2022 2023 2023 20% 10% 0% HIV Innovation sales as a % of total HIV Growth driven by oral 2DR and long-acting regimens . . Sales: £1.6bn in Q2 2023 with all regions driving growth Total portfolio: oral 2DR and LA regimens now 51% • Dovato. £430m and #1 HIV product • Dolutegravir: granted paediatric exclusivity by US FDA extending LOE by six months to April 2028 Cabenuva. £176m with SOLAR data driving strong growth with >70% of sales from competitor regimens Apretude. £36m; building strongly in US. Positive CHMP opinion in Europe Pipeline: three target medicine profiles focused on next- generation long-acting regimens 2023 outlook upgraded: high-single digit % growth Dovato GSK Juluca 1. Two drug regimen Cabenuva Apretude Oral 2DR & LA 18
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