RSV Seasonal Vaccine Introduction and Growth Strategy slide image

RSV Seasonal Vaccine Introduction and Growth Strategy

68 potential new vaccines and medicines in pipeline Phase-32 assets 2904545 4429016 3993129 4382276 4396687 4077164 3943104 3536867 2556286 3186899 3494245 3772701 3882347 3923868 4182137 (VIR-7832) 3965193 5251738 cabotegravir (1265744) 3739937 Recombinant protein, adjuvanted* Bioconjugated recombinant protein, adjuvanted* Adjuvanted recombinant subunit mRNA* mRNA* Bivalent GMMA* Recombinant protein, adjuvanted* Bivalent conjugate* Mtb cholesterol dependent inhibitor* CRK-12 inhibitor*2 Proteasome inhibitor* P. falciparum whole cell inhibitor* FimH antagonist* PI4K beta inhibitor Anti-spike protein antibody* PAPD5/PAPD7 inhibitor TLR8 agonist* Integrase inhibitor (400 mg/ml formulation) Maturation inhibitor Capsid protein inhibitor Capsid protein inhibitor Integrase inhibitor* 4004280 4011499 4524184 3888130 Anti-IL7 antibody* 1070806 Anti-IL18 antibody 4527226 (AL-101) 4074386 4381562 3745417 6097608 XMT-20563 (wholly owned by Mersana Theraprutics) belantamab (2857914) 4172239 Anti-sortilin antibody* Anti-LAG-3 antibody* Anti-PVRIG antibody* STING agonist Anti-CD96 antibody* STING agonist ADC* Anti-BCMA antibody DNMT1 inhibitor* C. difficile K. pneumoniae Cytomegalovirus' Seasonal flu COVID-19 Invasive non-typhoidal salmonella** Therapeutic herpes simplex virus Salmonella (typhoid + paratyphoid A) Tuberculosis Visceral leishmaniasis Visceral leishmaniasis Malaria Uncomplicated UTI Viral COPD exacerbations COVID-191 Hepatitis B virus' Hepatitis B virus HIV HIV HIV HIV HIV Multiple sclerosis Atopic dermatitis Alzheimer's disease Cancer Cancer Cancer Cancer Cancer Multiple myeloma Sickle cell disease Infectious diseases HIV (VIIV) Respiratory/Immunology Oncology Opportunity driven GSK *In-license or other alliance relationship with third party ** Additional indications or candidates also under investigation In registration 1. In phase I/II study 2. Transition activities underway to enable further progression by partner 3. GSK has an exclusive global license option to co-develop and commercialise the candidate 4. Imminent study start 5. GSK has exclusive option to co-develop post phase II 6. Phase II/III study start expected in 2023 7. Phase II study start expected in 2023 8. Approved in US and EU 9. Phase III study start expected in 2023 10. Phase III trial in patients with progranulin gene mutation 37 32
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