Investor Presentaiton

Company overview Financial performance Oncology Financial review 2022 priorities Appendix Innovation: Pipeline overview Innovation: Clinical trials Immunology Ophthalmology Neuroscience Respiratory Disease MIJ821 - NR2B negative allosteric modulator (NAM) NCT04722666 (CMIJ821A12201) Indication Phase Major depressiv disorder with acute suicidal ideation or behavior Phase 2 Patients Primary Outcome Measures Arms Intervention Target Patients Read-out Milestone(s) 195 Change from baseline to 24 hours in the total score of the Montgomery Åsberg Depression Rating Scale (MADRS) MIJ821 (mg/kg) very low dose for 40 minutes IV infusion on Day 1, Day 15 and Day 29 MIJ821 (mg/kg) low dose for 40 minutes IV infusion on Day 1, Day 15 and Day 29 MIJ821 (mg/kg) high dose for 40 minutes IV infusion on Day 1, Day 15 and Day 29 MIJ821 (mg/kg) very high dose for 40 minutes IV infusion on Day 1, Day 15 and Day 29 Placebo 40 minutes IV infusion of 0.9% sodium chloride on Day 1, Day 15 and Day 29 MIJ821 (mg/kg) high dose for 40 minutes IV infusion on Day 1 followed by Placebo 40 minutes IV infusion of 0.9% sodium chloride on Day 15 and Day 29 MIJ821 (mg/kg) very high dose for 40 minutes IV infusion on Day 1 followed by Placebo 40 minutes IV infusion of 0.9% sodium chloride on Day 15 and Day 29 Participants who have suicidal ideation with intent 2023 Publication TBD 85 Investor Relations | Q2 2022 Results References Abbreviations Cardio-Renal Global Health Biosimilars NOVARTIS | Reimagining Medicine

View entire presentation