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Investor Presentaiton

Leveraging precision medicine to improve outcomes for patients WELIREG MK-10841 MK-3543 Presented data at ESMO from Phase 3 LITESPARK-005 study for treatment of adults with previously treated advanced RCC, which showed statistically significant and clinically meaningful improvement in progression-free survival vs. everolimus (standard of care) • FDA granted priority review with target action date of January 17th Proceeding with additional Phase 3 studies • Presented data at ESMO for oral KRAS inhibitor as monotherapy in solid tumors and in combination with KEYTRUDA in patients with metastatic NSCLC whose tumors harbored KRAS G12C mutations • Began enrolling patients in Phase 3 study evaluating bomedemstat (LSD1 inhibitor) in 2L essential thrombocythemia 1. In collaboration with Taiho and Astex MERCK 23
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