2022 Highlights and ESG Progress

North America Highlights Larger customer base and enhanced customer experience through tailored products and services • Overall volumes growth, driven by most segments in Mexico and by CIB, CRE and Auto in the US Profitability remained high driven by outstanding results in Mexico and high profit in the US • In Q4, NII remained high, costs increased and LLPs normalization Loans €157bn +9% Efficiency 47.7% +1.9pp Key data and P&L Deposits Mutual Funds €136bn +14% €28bn 0% COR 1.49% +57bps ROTE¹ 20.5% -3.6pp P&L* Q4'22 % Q3'22 2022 % 2021 % 20212 NII 2,603 -0.3 9,705 6.6 20.2 Net fee income 508 -1.1 1,958 5.7 19.1 Total revenue 3,295 2.2 12,316 0.6 13.5 Operating expenses -1,632 6.1 -5,871 5.1 18.2 Net operating income LLPS 1,663 -1.4 6,445 -3.1 9.5 -872 24.6 -2,538 85.5 109.8 Underlying att. profit 607 -12.0 2,878 -14.1 -2.8 (*) € mn and % change in constant euros. Santander Note: 2022 data and YoY changes (loans, deposits and mutual funds in constant euros). (1) Adjusted ROTE: adjusted based on Group's deployed capital calculated as contribution of RWAs at 12%. Using tangible equity, ROTE is 11.1%. (2) % change in current euros. 39

View entire presentation