Novavax Global Commercial Operations and COVID-19 Vaccine Update

Novavax booster after EUA vaccines increases IgG responses Last dose of EUA vaccines >6 months prior to Novavax dose, 28 days post-boost Primary series of EUA vaccines + Novavax booster Primary series & boost of EUA vaccines + Novavax booster Anti-rS IgG GMT (EU/mL) with 95% CI 1,000,000 100,000 95% VE 10,000 1,000 100 88% VE* 263,387 294,763 95% VE* 88,670 75,136 47,456 88% VE* 116,473 91,465 93,597 10 2 doses NVX 2 doses PFE 2 doses MOD 1 dose J&J 3 doses NVX 3 doses PFE 3 doses MOD 2 doses J&J + NVX boost N=7 + NVX boost N=187 + NVX boost N=125 + NVX boost + NVX boost + NVX boost N=19 N=4 N=254 + NVX boost N=130 + NVX boost N=6 novavax *CoP from Fong et al., 2023. DOI: 10.1038/s41467-022-35768-3 © 2023 NOVAVAX. All rights reserved. 48

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