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Investor Presentaiton

Novo Nordisk Annual Report 2023 Introducing Novo Nordisk Strategic Aspirations Risks Management Consolidated statements Additional information ACCOUNTING POLICIES Waste is measured as the sum of all the waste disposed of at production sites based on weight receipts. Organic residues for recycling are waste from the production of the active pharmaceutical ingredients, where the energy is recovered in biogas plants and the digested slurry is used on local farmland as fertiliser. Ethanol is recovered in internal regeneration plants and re-used. Energy recovery is waste disposed of at waste-to-energy plants and at a biogas plant. Waste with no energy recovery covers water waste and other waste not suitable for other disposal methods, such as hazardous waste for incineration and various other types of waste. 7.5 Breaches of environmental regulatory limit values In 2023 there were 12 breaches compared to 8 in 2022. None of the breaches resulted in any correlated material negative impact on the environment. For all breaches, mitigation actions are in progress. ACCOUNTING POLICIES Breaches of regulatory limit values cover all breaches with limit values reported to the environmental authorities. Breaches related to the same continued exceedance at the same site count as one breach for the year. Section 8 Social performance 8.1 Patients reached with Novo Nordisk's Diabetes and Obesity care products Estimate in millions 2023 2022 2021 Patients reached with Novo Nordisk's Diabetes care products 40.5 36.3 34.6 Patients reached with Novo Nordisk's Obesity care products 1.1 0.6 0.3 Total number of patients reached 41.6 36.9 34.9 The estimated number of full-year patients reached with Novo Nordisk's Diabetes care products increased from 36.3 million in 2022 to 40.5 million in 2023. The 12% increase was primarily driven by the GLP-1 franchise, followed by the new-generation insulin franchise and the human insulin franchise. The increase in number of full-year patients reached with Novo Nordisk's Obesity care products in 2023 was primarily driven by the continued launch of WegovyⓇ in new markets. In 2023, the estimated number of full-year patients with diabetes reached with Novo Nordisk's human insulin vials through the Access to Insulin Commitment was 2.4 million, compared to 1.8 million in 2022. The 33% growth through the Access to Insulin Commitment was driven by increased sales through both government and private market channels, sold at or below the USD 3 ceiling price. Novo Nordisk also sold human insulin vials at or below the ceiling price of USD 3 in countries outside the Commitment, reaching an estimated additional 2.6 million patients in 2023. This represents a total of 5 million patients with diabetes reached with human insulin at or below USD 3 per vial globally. Through the Changing DiabetesⓇ in Children (CDIC) partnership, 52,249 children and youth were reached in total by the end of 2023, compared to 41,033 by the end of 2022. Almost half of the new enrolled children were reached through expansion in Asian countries, mainly India, Pakistan, Indonesia and Vietnam. The children receive access to diabetes care in clinics (e.g. patient education), as well as medical supplies if needed. ACCOUNTING POLICIES The number of full-year patients reached with Novo Nordisk's Diabetes and Obesity care products, excluding devices, is estimated by dividing Novo Nordisk's annual sales volume by the annual usage dose per patient for each product class, as defined by the WHO (for Diabetes) and in accordance with the dose strength of the product (for Obesity). The number of full-year patients reached with human insulin vials via the Novo Nordisk Access to Insulin Commitment is estimated by dividing Novo Nordisk's annual sales volume by the annual usage dose per patient reached via the Novo Nordisk Access to Insulin Commitment, as defined by the WHO. The WHO-defined daily dosage for these products may not accurately reflect the recommended or prescribed daily dose. Actual doses are based on individual characteristics (e.g. age and weight) and pharmacokinetic considerations. Despite this uncertainty, Novo Nordisk assesses this to be the most consistent way of reporting. The number of children reached with Diabetes care treatment through the Changing Diabetes® in Children programme is measured as the total accumulated number of children enrolled since the initiation of the partnership in 2009. 8.2 Employees Number of employees Number Year-end employees (total) Year-end number of full-time employees 2023 2022 64,319 63,370 55,185 54,393 2021 48,478 47,792 Employees by geographical area Number 2023 2022 2021 International Operations 56,004 47,935 42,372 Denmark 28,692 22,916 19,150 EMEA (Europe, the Middle East and Africa), excluding Denmark 8,808 7,954 7,530 6,485 6,148 5,833 12,019 10,917 9,859 8,315 7,250 6,106 64,319 55,185 48,478 China (Mainland China, Hong Kong, Taiwan) Rest of World (all other countries) North America Operations Year-end employees (total) 90
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