ANNUAL REPORT 2021

LUNDBECK ANNUAL REPORT 2021 = CONTENTS INDEPENDENT AUDITOR'S REPORTS CONTINUED Our responsibility is to obtain reasonable assurance on whether the annual report is prepared, in all material respects, in compliance with the ESEF Regulation based on the evidence we have obtained, and to issue a report that includes our opinion. The nature, timing and extent of procedures selected depend on the auditor's judgment, including the assessment of the risks of material departures from the requirements set out in the ESEF Regulation, whether due to fraud or error. The procedures include: • Testing whether the annual report is prepared in XHTML format; • Obtaining an understanding of the company's iXBRL tagging process and of internal control over the tagging process; • Evaluating the completeness of the iXBRL tagging of the consolidated financial statements; • Evaluating the appropriateness of the company's use of iXBRL elements selected from the ESEF taxonomy and the creation of extension elements where no suitable element in the ESEF taxonomy has been identified; • Evaluating the use of anchoring of extension elements to elements in the ESEF taxonomy; and • Reconciling the iXBRL tagged data with the audited consolidated financial statements. In our opinion, the Annual Report of H. Lundbeck A/S for the financial year 1 January to 31 December 2021 with the file name HLUNDBECK- 2021-12-31-en.zip is prepared, in all material respects, in compliance with the ESEF Regulation. Hellerup, 9 February 2022 PricewaterhouseCoopers Statsautoriseret Revisionspartnerselskab CVR No 3377 1231 Lars Baungaard State Authorized Public Accountant mne23331 John of Torben Jensen State Authorized Public Accountant mne18651 109/111

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