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Investor Presentation

TRX count (000s) NWA UTOTOO 20 10 60 50 40 30 90 80 70 0 0 6 12 18 134 Investor presentation First six months of 2022 Total RybelsusⓇ TRx volume is steadily growing in the US RybelsusⓇ and SGLT-2i¹ uptake in the US² since respective launches Rybelsus® TRX SGLT-2i TRX 78 • . In H1, RybelsusⓇ sales account for 20% share of growth of NAO sales Successful RybelsusⓇ launch despite COVID-19 impacting the first year of launch Rybelsus® TRX steadily increasing to above 60,000 Rx per week Time since launch (weeks) 96 102 108 114 120 126 132 138 60 60 1SGLT-2i is an average of empagliflozin and canagliflozin script count. 2Rybelsus® is based on Oct 2019 focus launch. Each data points represents a rolling four-week average. Note: NBRX: New-to-brand prescriptions; TRX: Total prescription data; Source: IQVIA Xponent, Weekly (ending 15th July 2022) NAO
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