Q4 2021 Results slide image

Q4 2021 Results

Participants Company overview Pharmaceuticals Oncology Financial review Conclusion Appendix Leqvio®: US launch underway FDA approved C E AZ K&K LEQVIO® Effective and sustained LDL-C reduction¹ with twice a year maintenance dose administered by HCP Broad label covering 16m US ASCVD patients not at LDL-C goal Go-to-market model designed to overcome clinical barriers and address access, adherence and affordability Sales, reimbursement and medical field teams trained and deployed Robust network of AICs to provide acquisition and administration flexibility Value-based price per dose of USD 3,250 Comprehensive patient and HCP support programs available to ensure timely access Product available from specialty distributors since early January Filed for permanent J-Code, miscellaneous J-Code for temporary use available Expect modest initial ramp as we lay the foundation for multi-blockbuster potential LDL-C - Low Density Lipoprotein Cholesterol ASCVD Atherosclerotic Cardiovascular Disease AIC - Alternative Injection Center HCP Healthcare Professional 1. Across the 6-month dosing interval. 30 Investor Relations | Q4 2021 Results ✓ NOVARTIS | Reimagining Medicine
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