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Investor Presentaiton

Investor Presentation First nine months of 2018 Slide 38 Region Latin America at a glance Diabetes trend in population Population with diabetes Diabetes market by value and Novo Nordisk market share Novo Nordisk reported sales Million 80 Diabetes growth rate NN Insulin MS NN OAD MS bDKK 16 NN GLP-1 MS First nine months of 2018 Sales (mDKK) YTD growth² 120% 66% Long-acting insulin³ 528 27% 100% Premix insulin4 92 14% 60 105% 40 68 12 Fast-acting insulin5 246 34% 9.3%¹ 80% Human insulin 577 4% Insulin 7.8%¹ Total insulin 8 60% 1,443 18% 41 GLP-16 392 29% 40% 20 20 Other diabetes care? 48 38% 4 6.8%¹ 20 OAD 20% Diabetes care 1,883 20% Obesity (SaxendaⓇ) 277 69% 0 2000 2017 2045 Aug 2013 0% Biopharm³ 876 72% Aug 2018 Total 3,036 35% Latin America population 2018: ~0.6 billion people and diabetes prevalence ~9.3% Source: International Diabetes Federation: Diabetes Atlas 1th Edition 2000 and Diabetes Atlas 8th Edition 2017 1 CAGR calculated for last 5-year period Competitor value market share for insulin as of Aug 2018: Sanofi 32% and Eli Lilly 19% Competitor value market share for GLP-1 as of Aug 2018: Eli Lilly 30% and AstraZeneca 1% OAD: Oral anti-diabetic; MS: Market share Source: IQVIA MAT Aug, 2018 value figures 2 Percentage change in local currency from YTD Q3 2017 to YTD Q3 2018 3 Comprises Tresiba®, XultophyⓇ and Levemir®; 4 Comprises NovoMixⓇ and RyzodegⓇ; 5 Comprises NovoRapidⓇ; 6 Comprises VictozaⓇ; 7 Comprises Novo NormⓇ and needles; 8 Comprises primarily NovoSeven®, Novo Eight® and Norditropin®
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