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Investor Presentation

122 Investor presentation First six months of 2022 Rest of World at a glance Rest of World Diabetes trend Million 21% DKK billion Diabetes market by value and Novo Nordisk market share Novo Nordisk reported sales First half of 2022 Sales (mDKK) Growth² 300 Total GLP-13 3,526 92% 250 18% 80% Long-acting insulin4 1,285 9% Premix insulin5 1,292 3% 60 GLP-1 200 Fast-acting insulin 1,201 7% 31%1 60% Insulin Human insulin 1,321 -11% 150 286 40 40 1%1 Total insulin 5,099 1% 40% Other Diabetes care? 279 15% 227 100 187 Diabetes care 8,904 25% 20 20 4%1 OAD 20% Obesity care 886 29% 50 (SaxendaⓇ) Diabetes & Obesity 9,790 25% 0 2021 0 0% care 2030 2045 May 2017 May 2022 Rare disease8 2,667 7% Population with diabetes Diabetes growth rate Total 12,457 21% GLP-1 MS -Insulin MS OAD MS Diabetes trend estimates based on the following International Diabetes Foundation defined regions: South & Central America, Southeast Asia Source: International Diabetes Federation: Diabetes Atlas 10th Edition 2021 1 CAGR calculated for last 5-year period Competitor insulin value market shares, as of May 2022: Novo Nordisk 57%, Sanofi 24% and Eli Lilly 14%; Competitor GLP-1 value market shares, as of May 2022: Novo Nordisk 62%, Eli Lilly 37% and AstraZeneca 1% OAD: Oral anti-diabetic; MS: Market Share; Source: IQVIA MAT, May 2022 value figures 2 At constant exchange rates; 3 Comprises Victoza®, OzempicⓇ and RybelsusⓇ; 4 Comprises TresibaⓇ, XultophyⓇ and LevemirⓇ: 5 Comprises NovoMixⓇ and RyzodegⓇ6 Comprises NovoRapidⓇ and Fiasp®;7 Comprises Novo NormⓇ and needles; 8 Comprises primarily Esperoct®, Refixia ®, NovoSeven®, NovoEight® and NorditropinⓇ Source: Quarterly company announcement
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