EVOLUTION AT MERCK - INVENTING FOR LIFE

KEYTRUDA: BROAD ACTIVITY IN >25 CANCER TYPES Change from baseline in tumor size (%) Melanoma NSCLC H&N Urothelial TNBC Gastric CHL 100 100 100 100 100 100 100 0 0 0 0 -100 -100 -100 -100 -100 -100 -100 NHL PMBCL Mesothelioma Ovarian SCLC Esophageal NPC Anal ☐ 100 100 1 100 100 100 100 100 0 = cancer types with approved indications -100 -100 -100 -100 -100 -100 -100 Biliary Tract HCC ER+/HER2- BC Cervical Thyroid Salivary Endometrial CCRCC 100 100 100 100 100 100 100 100 0 0 0 -100 -100 -100 -100 -100 -100 -100 -100 Prostate GBM MSI-H CRC MSI-H non-CRO Carcinoid PNET Merkel Cell nccRCC 100 100 100 100 100 100 100 100 0 0 0 0 0 0 -100 -100 -100 -100 -100 -100 -100 -100 MERCK H Dr. Roy Baynes H INVENTING FOR LIFE 49

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