Investor Presentaiton

4Rs Mission CRL has reframed the 3Rs (Reduction, Refinement and Replacement) to include a fourth R: Responsibility 閨 Responsibility Leading progressive change within the g industry regarding animal use through cooperative efforts internally, with clients, and regulatory agencies Fij Replacement Partnering and investing in technology alternatives to animal models, such as Endosafe® cartridge technology, in vitro oncology models, in silico approaches Reduction Collaborating with clients on study design to minimize the use of animal models, including validating Virtual Control Groups Refinement Developing procedures that significantly reduce impacts on animals, such as less invasive identification methods, harmonized blood collection guidelines, species appropriate social housing, and species- specific behavioral trainings Advancing Responsible Science Committed to continuing to lead the industry in the next frontier of drug development Charles River Laboratories (CRL) 6

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