Vaxcyte Corporate Presentation

Serotype Replacement Drives Need for Broader-Spectrum Vaccines Non-Vaccine Serotypes Increase in Prevalence, as Circulation of Vaccine Serotypes is Eliminated, Resulting in the Need for Broader-Spectrum Vaccines Cases Per 100,000 UK IPD Cases in Adults > 65 (1) Prevnar 13 Types Non-vaccine Types (1) Ladhani et al, Lancet Infect Dis 2018 Apr;18(4):441-45 inclusive of unpublished raw data. 30 25 20 15 10 5 0 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 11 2016 Residual disease driven by incremental 11 strains over and above PCV13. PCV13 highly effective in prevention of invasive PD and circulation of included strains. о

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