BioNTech Investor Day Presentation Deck
BNT151 mediates CAR T cell expansion in non-tumor bearing mice
# CAR Ts = Total flus [p/s]
108
107
Data on file.
Tuto
Comparable in vivo expansion of CAR T cells in CLDN6-LPX or BNT151 treated mice
5
Days post ACT
10
CAR T dose
2x106
2x106
2x106
2x107
Treatment
+ CLDN6-LPX
+ BNT 151
+ CLDN6-LPX + BNT151
+ ctrl-LPX + crtl-LNP
Treatment
Time point of analysis
Day 1
(Baseline)
1° treatment - Day 1
Day 4
Day 7
2° treatment Day 7
Day 9
Day 10
CLDN6-CAR-BBz-Luc-GFP positive T cells
2x106
2x107
CLDN6-LPX
CLDN6-LPX
BNT151
BNT 151
NUM
C6-LPX+ BNT151 Ctr-LPX + ctrl-LNP
C6-LPX+ BNT151 Ctr-LPX + ctrl-LNP
Splenocytes isolated for ex vivo cytotox assay
BNT151 treatment leads to initial similar CAR T cell expansion in vivo compared to CLDN6-LPX treatment
BNT151-mediated CAR T expansion peaks at day 3/4 after treatment, followed by contraction phase at day 7
CLDN6-LPX + BNT151 improves CAR T cell expansion
RiboCytokines
10.0
8.0
6.0 x105
4.0
2.0
Radiance
(p/sec/cm²/sr)
Color Scale
Min = 2.00e5
Max 1.00e6
BIONTECH
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