American Thoracic Society - Sanofi Investor Call

Pharmacological Treatment for COPD DYSPNEA LABA or LAMA LABA + LAMA EXACERBATIONS LABA or LAMA if blood eos <300 if blood eos ≥300 LABA + LAMA • Consider switching inhaler device or molecules • Implement or escalate non- pharmacological treatment(s) • Investigate and treat other causes of dyspnea if blood eos <100 if blood eos ≥100 L LABA + LAMA + ICS Roflumilast ATS 2023 FEV₁ <50% & chronic bronchitis Azithromycin Preferentially in former smokers Global Strategy for Diagnosis, Management and Prevention of COPD 2023 Report 16

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