Investor Presentaiton

BIOND BIOLOGICS BND-22 enhances anti-tumor activity in-vivo Melanoma lung lesion + PBMC Tumor cells (MEL526) SCID-NOD mice S ↑ Abs IV ↑↑ PBMC IV 0 5 10 15 20 25 ↑ ↑ Lung metastasis evaluation 50 Tumor only Donor 1 Donor 2 Donor 3 PBMC + IgG PBMC + BND-22 Naïve Tumor weight (mg) 500 TGI = 58% 400- 300 200 100 SC colon cancer+ macrophages Tumor cells (COLO-320) NSG 03 7 10 Monitor tumor growth mice Macrophages Abs ↑sc Tiv Tiv Tiv Tumor vo,ume (mmĂ) 1000 500 Mo + control IgG 20 25 30 35 Days Tumor vo,ume (mmĂ) 1000 500 T Mo + BND-22 TGI = 91% 20 25 30 35 Days Tumor weight was calculated by subtracting naïve mice lung weight form the lung weight of the different mice. TGI - tumor growth inhibition. 涯 Isotype BND-22 *P<0.05, Student's T test compared to control IgG. N = 5-9 mice for each group. control Biond Biologics Corporate Presentation | May 2021 | Non-confidential 11

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