Investor Presentaiton

4 Leading Functional Genomics and Synthetic Lethality Platform The Next Frontier in Precision Medicine Oncology Functional Genomics and SL provides a powerful approach to discover novel precision medicine therapies with patient biomarkers, including MTAP-deletion (~15% of solid tumors), BRCA/HRD (Breast, Prostate, Ovarian, Others), and high-MSI (15% GI Cancers) nature REVIEWS GENETICS • Functional genomics combines human genetics with advances in Al and machine learning to develop effective precision medicines Synthetic lethality occurs when the simultaneous perturbation of two genes results in cell death • Large-scale screening for novel synthetic lethal targets has progressed through advances in molecular biology (e.g., RNA interference, CRISPR-Cas9 editing) and bioinformatics RNA processing Chromatin & transcription Ribosome & translation Mitochondria Peroxisome Nature Reviews Genetics, Vol. 18, 2017, Hieter, et al., as edited by IDEAYA Metabolism & amino acid biosynthesis Secretion & vesicle transport Protein folding & glycosylation Cell wall biosynthesis Nuclear- cytoplasmic transport Nuclear migration & protein degradation Reference: Charles Boone Mitosis & chr. segregation DNA replication & repair Cell polarity & morphogenesis - IDEAVA BIOSCIENCES

View entire presentation